Research appearing in the Archives of Internal Medicine (2007;167:188-194) shows a connection between the use of  selective serotonin reuptake inhibitors (also called SSRIs—these are drugs like Prozac and other commonly used anti depressants) and fracture. Over 5000 subjects over the age of 50 were monitored for a period of five years. The researchers found that there was both an increase in the demineralization of bone in the users of these drugs. Use of the drugs also increased the odds of falling. Overall, users of the drug had a two-fold increase of a clinical fragility fracture.