Research appearing in Supportive Care in Cancer (December 2012, Volume 20, Issue 12, pp 3129-3135) looked at supplementation and its effect on inflammation in patients receiving chemotherapy. The subjects of the study were 31 patients with stage III or IV squalors cell carcinoma in the head or neck. Supplementation (containing amino acids, omega-3 fatty acids, RNA, vitamins and antioxidents, called Oral Impact®) was given during five days before each cycle of chemotherapy. Biological samples were collected at baseline, after five days of oral supplementation and before the last cycle of chemotherapy. Acute phase proteins levels, proteomic cytokines determination and urinary isoprostanes levels were used as inflammatory and oxidative stress biomarkers. Toxicities were followed up during radiochemotherapy. After five days of supplementation, there was a decrease in inflammation. The supplement also seemed to reduce the incidence of severe acute mucositis (painful inflammation and ulceration of the mucous membranes lining the digestive tract).
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