Research appearing in the Journal of Crohns and Colitis (2012 May; 6(4):405-11) looked at four studies exploring the effect of vitamin D supplementation on patients with colitis. All studies showed improvement in the disease, with no major adverse effects from vitamin D supplementation.

Another study (J Steroid Biochem Mol Biol 2018 Jan;175:23-28), found that vitamin D supplementation was beneficial for these patients. The author stated, “While a number of studies have consistently revealed an association between CD and vitamin D deficiency, recent experimental work has uncovered a compelling mechanistic basis for the contribution of vitamin D deficiency to the pathogenesis of the disease. Moreover, a number of intervention trials have provided generally solid evidence that robust vitamin D supplementation may be of therapeutic benefit to patients with CD. This review summarizes these laboratory and clinical findings. “