In a double-blind, placebo-controlled study published in the Journal of the American College of Nutrition (1992;11(2):159- 163), B vitamins were given to geriatric patients suffering from depression. It was found that taking thiamin, riboflavin and pyridoxine (10 mg/day of each) created improvement in depression rating and cognitive function scores. The vitamins seemed to potentiate the antidepressant medication the subjects were taking. Interestingly, B12 levels increased in the treatment group, but not in the control group. B12 was not one of the supplements given.