Research appearing in the Western Journal of Surgery, Obstetrics, and Gynecology (1954;62:610-611) looked at the effect niacin and vitamin C with rutin had on dysmenorrhea. The subjects of the study were 220 women between the ages of 15 and 44 with dysmenorrhea, 80 of them completed the treatment. They were given 100 mg. of niacin twice each day, taking more (100 mg. every 2-3 hours) when menstrual cramps were present. Supplementation relieved symptoms in 90% of the cases. Giving 300 mg. of vitamin C with 60 mg. of rutin (a flavonoid) improved the efficacy of the niacin.
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