Research that appeared in the Journal of Clinical Oncology (April 20, 2012 vol. 30 no. 12 1280-1287) found a connection between the types of fatty acids in the diet and inflammation and fatigue in breast cancer patients. The subjects of the study were 633 breast cancer survivors who were participating in the Health, Eating, Activity and Lifestyle Study. The subjects completed a food frequency/dietary supplement questionnaire and provided a blood sample assayed for C-reactive protein (CRP–a measurement of inflammation) and serum amyloid A (30 months after diagnosis) and completed the Piper Fatigue Scale and Short Form-36 (SF-36) vitality scale (39 months after diagnosis). Survivors with high CRP tended to have more fatigue. Also, subjects with a higher intake of omega-6 fatty acids compared to omega-3 fatty acids tended to have higher CRP levels. According to the authors, ” Results link higher intake of ω-3 PUFAs (omega-3 fatty acids–like those found in fish oil), decreased inflammation, and decreased physical aspects of fatigue. Future studies should test whether ω-3 supplementation may reduce fatigue among significantly fatigued breast cancer survivors. “