The Journal of Agriculture and Food Chemistry (2006; 54(14): 5203-7) published a study involving mice, apigenin, was found to reduce inflammatory substances produced by an allergic reaction. Apigenin is a flavonoid. Flavonoids are plant antioxidants that have anti-inflammatory and anti-tumor activity. Apigenin is found in high amounts in several herbs including parsley, thyme, and peppermint.
The mice were divided into two groups. One was the control group and the other was given apigenin as part of their diet for two weeks. IgE (immunoglobulin E), which is associated with allergies, was significantly lower in the mice receiving the flavonoid. Inflammatory substances associated with allergies (certain cytokines) were also lower in the supplemented group.