According to a small research study (Biochem Biophys Res Commun 100:972-7, 1981). A small group of students (12/27) who were not supplemented were challenged with a large dose MSG and showed characteristic symptoms. For 12 weeks nine of the students received 50 mg. of pyridoxine (vitamin B6) per day, the other three took a placebo. When challenged with MSG after the supplementation, 8/9 of the supplemented students did not react to the MSG. Another study, conducted on rats appeared in J Nutr. (1972 Jul;102(7):835-40) showed B6 to help with the utilization of MSG.